EC - 3-keto-5-aminohexanoate cleavage enzyme

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IntEnz Enzyme Nomenclature


Accepted name:
3-keto-5-aminohexanoate cleavage enzyme
Other name:
kce (gene name)
Systematic name:
(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase




Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, is involved in the anaerobic fermentation of lysine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Barker, H. A., Kahn, J. M., Hedrick, L.
    Pathway of lysine degradation in Fusobacterium nucleatum.
    J. Bacteriol. 152: 201-207 (1982). [PMID: 6811551]
  2. Kreimeyer, A., Perret, A., Lechaplais, C., Vallenet, D., Medigue, C., Salanoubat, M., Weissenbach, J.
    Identification of the last unknown genes in the fermentation pathway of lysine.
    J. Biol. Chem. 282: 7191-7197 (2007). [PMID: 17166837]
  3. Bellinzoni, M., Bastard, K., Perret, A., Zaparucha, A., Perchat, N., Vergne, C., Wagner, T., de Melo-Minardi, R. C., Artiguenave, F., Cohen, G. N., Weissenbach, J., Salanoubat, M., Alzari, P. M.
    3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
    J. Biol. Chem. 286: 27399-27405 (2011). [PMID: 21632536]

[EC created 2015]