EC 1.14.99.50 - γ-glutamyl hercynylcysteine S-oxide synthase

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IntEnz Enzyme Nomenclature
EC 1.14.99.50

Names

Accepted name:
γ-glutamyl hercynylcysteine S-oxide synthase
Other name:
EgtB
Systematic name:
hercynine,γ-L-glutamyl-L-cysteine:oxygen (γ-L-glutamyl-S-hercyn-2-yl-L-cysteine S-oxide-forming)

Reaction

Cofactor

Comments:

Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and γ-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Seebeck, F. P.
    In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
    J. Am. Chem. Soc. 132: 6632-6633 (2010). [PMID: 20420449]
  2. Pluskal, T., Ueno, M., Yanagida, M.
    Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
    PLoS ONE 9: e97774 (2014). [PMID: 24828577]

[EC 1.14.99.50 created 2015]