EC 6.3.4.24 - Tyramine—L-glutamate ligase

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IntEnz Enzyme Nomenclature
EC 6.3.4.24

Names

Accepted name:
tyramine—L-glutamate ligase
Other name:
mfnD (gene name)
Systematic name:
tyramine:L-glutamate γ-ligase (ADP-forming)

Reaction

Cofactor

Comments:

The enzyme, which has been characterized from the archaea Methanocaldococcus fervens, participates in the biosynthesis of the cofactor methanofuran. Requires a divalent cation for activity, with Mn2+ giving the highest activity, followed by Mg2+, Co2+, Zn2+, and Fe2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Wang, Y., Xu, H., Harich, K. C., White, R. H.
    Identification and characterization of a tyramine-glutamate ligase (MfnD) involved in methanofuran biosynthesis.
    Biochemistry 53: 6220-6230 (2014). [PMID: 25211225]

[EC 6.3.4.24 created 2014]