EC 4.1.1.99 - Phosphomevalonate decarboxylase

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IntEnz Enzyme Nomenclature
EC 4.1.1.99

Names

Accepted name:
phosphomevalonate decarboxylase
Systematic name:
ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)

Reaction

Comments:

The enzyme participates in a mevalonate pathway that occurs in archaea other than the extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.110, bisphosphomevalonate decarboxylase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Vannice, J. C., Skaff, D. A., Keightley, A., Addo, J. K., Wyckoff, G. J., Miziorko, H. M.
    Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway.
    J. Bacteriol. 196: 1055-1063 (2014). [PMID: 24375100]

[EC 4.1.1.99 created 2014, modified 2018]