EC - Cypemycin N-terminal methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
cypemycin N-terminal methyltransferase
Other name:
Systematic name:
S-adenosyl-L-methionine:N-terminal L-alanine-[cypemycin] N-methyltransferase



The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of oligopeptides, cyclic peptides such as nisin and haloduracin, and the ε-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Claesen, J., Bibb, M.
    Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.
    Proc. Natl. Acad. Sci. U.S.A. 107: 16297-16302 (2010). [PMID: 20805503]
  2. Zhang, Q., van der Donk, W. A.
    Catalytic promiscuity of a bacterial alpha-N-methyltransferase.
    FEBS Lett. 586: 3391-3397 (2012). [PMID: 22841713]

[EC created 2014]