EC 2.7.1.183 - Glycoprotein-mannosyl O6-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.183

Names

Accepted name:
glycoprotein-mannosyl O6-kinase
Other names:
SGK196
protein O-mannose kinase
Systematic name:
ATP:O3-[N-acetyl-β-D-galactosaminyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→4)-α-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase

Reactions

Comments:

In humans this phosphorylated trisaccharide is attached to an L-threonine residue of α-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Yoshida-Moriguchi, T., Willer, T., Anderson, M. E., Venzke, D., Whyte, T., Muntoni, F., Lee, H., Nelson, S. F., Yu, L., Campbell, K. P.
    SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
    Science 341: 896-899 (2013). [PMID: 23929950]

[EC 2.7.1.183 created 2014]