EC 2.1.1.296 - Methyltransferase cap2

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IntEnz Enzyme Nomenclature
EC 2.1.1.296

Names

Accepted name:
methyltransferase cap2
Other names:
MTR2
cap2-MTase
mRNA (nucleoside-2'-O)-methyltransferase [ambiguous]
Systematic name:
S-adenosyl-L-methionine:5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-ribonucleotide-[mRNA] 2'-O-methyltransferase

Reaction

Comments:

The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the nucleoside at the second transcribed position of mRNAs and snRNAs. This methylation is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57, cap1 methyltransferase), but with lower efficiency [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (74) [show] [UniProt]

References

  1. Arhin, G. K., Ullu, E., Tschudi, C.
    2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.
    Mol. Biochem. Parasitol. 147: 137-139 (2006). [PMID: 16516986]
  2. Werner, M., Purta, E., Kaminska, K. H., Cymerman, I. A., Campbell, D. A., Mittra, B., Zamudio, J. R., Sturm, N. R., Jaworski, J., Bujnicki, J. M.
    2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
    Nucleic Acids Res. 39: 4756-4768 (2011). [PMID: 21310715]

[EC 2.1.1.296 created 2014]