EC - Cobalt-precorrin-8 methylmutase

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IntEnz Enzyme Nomenclature


Accepted name:
cobalt-precorrin-8 methylmutase
Other name:
cbiC (gene name)
Systematic name:
precorrin-8 11,12-methylmutase



The enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement. The equivalent enzyme in the aerobic pathway is EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043778


  1. Roessner, C. A., Warren, M. J., Santander, P. J., Atshaves, B. P., Ozaki, S., Stolowich, N. J., Iida, K., Scott, A. I.
    Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis.
    FEBS Lett. 301 : 73-78 (1992). [PMID: 1451790]
  2. Roth, J. R., Lawrence, J. G., Rubenfield, M., Kieffer-Higgins, S., Church, G. M.
    Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.
    J. Bacteriol. 175 : 3303-3316 (1993). [PMID: 8501034]
  3. Xue, Y., Wei, Z., Li, X., Gong, W.
    The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis.
    J. Struct. Biol. 153 : 307-311 (2006). [PMID: 16427313]
  4. Moore, S. J., Lawrence, A. D., Biedendieck, R., Deery, E., Frank, S., Howard, M. J., Rigby, S. E., Warren, M. J.
    Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
    Proc. Natl. Acad. Sci. U.S.A. 110 : 14906-14911 (2013). [PMID: 23922391]

[EC created 2014]