EC 2.8.2.36 - Desulfo-A47934 sulfotransferase

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IntEnz Enzyme Nomenclature
EC 2.8.2.36

Names

Accepted name:
desulfo-A47934 sulfotransferase
Other name:
StaL
Systematic name:
3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase

Reaction

Comments:

The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lamb, S. S., Patel, T., Koteva, K. P., Wright, G. D.
    Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL.
    Chem. Biol. 13: 171-181 (2006). [PMID: 16492565]
  2. Shi, R., Lamb, S. S., Bhat, S., Sulea, T., Wright, G. D., Matte, A., Cygler, M.
    Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis.
    J. Biol. Chem. 282: 13073-13086 (2007). [PMID: 17329243]

[EC 2.8.2.36 created 2014]