EC - N-acetylaspartylglutamate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
N-acetylaspartylglutamate synthase
Other names:
N-acetylaspartylglutamate synthetase
NAAG synthetase
RIMKLA (gene name) [ambiguous]
RIMKLB (gene name) [ambiguous]
Systematic name:
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming)



The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC, β-citrylglutamate synthase [2], while another isoform has the activity of EC, N-acetylaspartylglutamylglutamate synthase [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Becker, I., Lodder, J., Gieselmann, V., Eckhardt, M.
    Molecular characterization of N-acetylaspartylglutamate synthetase.
    J. Biol. Chem. 285: 29156-29164 (2010). [PMID: 20643647]
  2. Collard, F., Stroobant, V., Lamosa, P., Kapanda, C. N., Lambert, D. M., Muccioli, G. G., Poupaert, J. H., Opperdoes, F., Van Schaftingen, E.
    Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
    J. Biol. Chem. 285: 29826-29833 (2010). [PMID: 20657015]
  3. Lodder-Gadaczek, J., Becker, I., Gieselmann, V., Wang-Eckhardt, L., Eckhardt, M.
    N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
    J. Biol. Chem. 286: 16693-16706 (2011). [PMID: 21454531]

[EC created 2014]