EC 2.6.1.105 - Lysine—8-amino-7-oxononanoate transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.105

Names

Accepted name:
lysine—8-amino-7-oxononanoate transaminase
Other names:
DAPA aminotransferase [ambiguous]
bioA (gene name) [ambiguous]
bioK (gene name)
Systematic name:
L-lysine:8-amino-7-oxononanoate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine—8-amino-7-oxononanoate transaminase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Van Arsdell, S. W., Perkins, J. B., Yocum, R. R., Luan, L., Howitt, C. L., Chatterjee, N. P., Pero, J. G.
    Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.
    Biotechnol. Bioeng. 91: 75-83 (2005). [PMID: 15880481]
  2. Dey, S., Lane, J. M., Lee, R. E., Rubin, E. J., Sacchettini, J. C.
    Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
    Biochemistry 49: 6746-6760 (2010). [PMID: 20565114]

[EC 2.6.1.105 created 2014]