EC - Homogentisate phytyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
homogentisate phytyltransferase
Other names:
VTE2 (gene name)
Systematic name:
phytyl diphosphate:homogentisate phytyltransferase




Requires Mg2+ for activity [3]. Involved in the biosynthesis of the vitamin E tocopherols. While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC, homogentisate geranylgeranyltransferase), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate [1,3,4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Collakova, E., DellaPenna, D.
    Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
    Plant Physiol. 127 : 1113-1124 (2001). [PMID: 11706191]
  2. Savidge, B., Weiss, J. D., Wong, Y. H., Lassner, M. W., Mitsky, T. A., Shewmaker, C. K., Post-Beittenmiller, D., Valentin, H. E.
    Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp. PCC 6803 and Arabidopsis.
    Plant Physiol. 129 : 321-332 (2002). [PMID: 12011362]
  3. Sadre, R., Gruber, J., Frentzen, M.
    Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
    FEBS Lett. 580 : 5357-5362 (2006). [PMID: 16989822]
  4. Yang, W., Cahoon, R. E., Hunter, S. C., Zhang, C., Han, J., Borgschulte, T., Cahoon, E. B.
    Vitamin E biosynthesis: functional characterization of the monocot homogentisate geranylgeranyl transferase.
    Plant J. 65 : 206-217 (2011). [PMID: 21223386]

[EC created 2014]