EC 1.3.1.106 - Cobalt-precorrin-6A reductase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.3.1.106

Names

Accepted name:
cobalt-precorrin-6A reductase
Other name:
cbiJ (gene name)
Systematic name:
cobalt-precorrin-6B:NAD+ oxidoreductase

Reaction

Comments:

The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of cobalt-precorrin-6A. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. See EC 1.3.1.54 for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kim, W., Major, T. A., Whitman, W. B.
    Role of the precorrin 6-X reductase gene in cobamide biosynthesis in Methanococcus maripaludis.
    Archaea 1 : 375-384 (2005). [PMID: 16243778]
  2. Moore, S. J., Lawrence, A. D., Biedendieck, R., Deery, E., Frank, S., Howard, M. J., Rigby, S. E., Warren, M. J.
    Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
    Proc. Natl. Acad. Sci. U.S.A. 110 : 14906-14911 (2013). [PMID: 23922391]

[EC 1.3.1.106 created 2014]