EC - Cobalt-precorrin-6A reductase

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IntEnz Enzyme Nomenclature


Accepted name:
cobalt-precorrin-6A reductase
Other name:
cbiJ (gene name)
Systematic name:
cobalt-precorrin-6B:NAD+ oxidoreductase



The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of cobalt-precorrin-6A. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. See EC for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kim, W., Major, T. A., Whitman, W. B.
    Role of the precorrin 6-X reductase gene in cobamide biosynthesis in Methanococcus maripaludis.
    Archaea 1 : 375-384 (2005). [PMID: 16243778]
  2. Moore, S. J., Lawrence, A. D., Biedendieck, R., Deery, E., Frank, S., Howard, M. J., Rigby, S. E., Warren, M. J.
    Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
    Proc. Natl. Acad. Sci. U.S.A. 110 : 14906-14911 (2013). [PMID: 23922391]

[EC created 2014]