EC 3.3.2.13 - Chorismatase

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IntEnz Enzyme Nomenclature
EC 3.3.2.13

Names

Accepted name:
chorismatase
Other names:
chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase
fkbO (gene name)
rapK (gene name)
Systematic name:
chorismate pyruvate-hydrolase

Reaction

Comments:

The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Andexer, J. N., Kendrew, S. G., Nur-e-Alam, M., Lazos, O., Foster, T. A., Zimmermann, A. S., Warneck, T. D., Suthar, D., Coates, N. J., Koehn, F. E., Skotnicki, J. S., Carter, G. T., Gregory, M. A., Martin, C. J., Moss, S. J., Leadlay, P. F., Wilkinson, B.
    Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
    Proc. Natl. Acad. Sci. U.S.A. 108: 4776-4781 (2011). [PMID: 21383123]
  2. Juneja, P., Hubrich, F., Diederichs, K., Welte, W. and Andexer, J.N.
    Mechanistic implications for the chorismatase FkbO based on the crystal structure.
    J. Mol. Biol. (2013). [PMID: 24036425]

[EC 3.3.2.13 created 2013]