EC 2.4.2.55 - Nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.2.55

Names

Accepted name:
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
Other name:
ArsAB
Systematic name:
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase

Reaction

Comments:

The enzyme is involved in the biosynthesis of phenolic cobamides in the Gram-positive bacterium Sporomusa ovata. It can also transfer the phospho-D-ribosyl group to 4-methylphenol and 5,6-dimethylbenzimidazole. The related EC 2.4.2.21, nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase, also transfers the phospho-D-ribosyl group from nicotinate D-ribonucleotide to 5,6-dimethylbenzimidazole, but shows no activity with 4-methylphenol or phenol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Chan, C. H., Escalante-Semerena, J. C.
    ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.
    Mol. Microbiol. 81: 952-967 (2011). [PMID: 21696461]

[EC 2.4.2.55 created 2013]