EC - Heme oxygenase (staphylobilin-producing)

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IntEnz Enzyme Nomenclature


Accepted name:
heme oxygenase (staphylobilin-producing)
Other names:
haem oxygenase [ambiguous]
heme oxygenase (decyclizing) [ambiguous]
heme oxidase [ambiguous]
haem oxidase [ambiguous]
heme oxygenase [ambiguous]
isdG (gene name)
isdI (gene name)
Systematic name:
protoheme,hydrogen-donor:oxygen oxidoreductase (δ/β-methene-oxidizing, hydroxylating)



This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % δ-staphylobilin, respectively.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (25) [show] [UniProt]


  1. Reniere, M. L., Ukpabi, G. N., Harry, S. R., Stec, D. F., Krull, R., Wright, D. W., Bachmann, B. O., Murphy, M. E., Skaar, E. P.
    The IsdG-family of haem oxygenases degrades haem to a novel chromophore.
    Mol. Microbiol. 75: 1529-1538 (2010). [PMID: 20180905]
  2. Matsui, T., Nambu, S., Ono, Y., Goulding, C. W., Tsumoto, K., Ikeda-Saito, M.
    Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide.
    Biochemistry 52: 3025-3027 (2013). [PMID: 23600533]
  3. Streit, B. R., Kant, R., Tokmina-Lukaszewska, M., Celis, A. I., Machovina, M. M., Skaar, E. P., Bothner, B., DuBois, J. L.
    Time-resolved Studies of IsdG Protein Identify Molecular Signposts along the Non-canonical Heme Oxygenase Pathway.
    J. Biol. Chem. 291: 862-871 (2016). [PMID: 26534961]

[EC created 2013, modified 2017]