EC 1.1.1.363 - Glucose-6-phosphate dehydrogenase [NAD(P)+]

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IntEnz Enzyme Nomenclature
EC 1.1.1.363

Names

Accepted name:
glucose-6-phosphate dehydrogenase [NAD(P)+]
Other names:
G6PDH
G6PD
Glc6PD
Systematic name:
D-glucose-6-phosphate:NAD(P)+ 1-oxidoreductase

Reactions

Comments:

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP+ while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD+. cf. EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+) and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Olive, C., Geroch, M. E., Levy, H. R.
    Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.
    J. Biol. Chem. 246: 2047-2057 (1971). [PMID: 4396688]
  2. Lee, W. T., Levy, H. R.
    Lysine-21 of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase participates in substrate binding through charge-charge interaction.
    Protein Sci. 1: 329-334 (1992). [PMID: 1304341]
  3. Cosgrove, M. S., Naylor, C., Paludan, S., Adams, M. J., Levy, H. R.
    On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
    Biochemistry 37: 2759-2767 (1998). [PMID: 9485426]
  4. Ragunathan, S., Levy, H. R.
    Purification and characterization of the NAD-preferring glucose 6-phosphate dehydrogenase from Acetobacter hansenii (Acetobacter xylinum).
    Arch. Biochem. Biophys. 310: 360-366 (1994). [PMID: 8179320]

[EC 1.1.1.363 created 2013, modified 2015]