EC 2.6.99.3 - O-ureido-L-serine synthase

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IntEnz Enzyme Nomenclature
EC 2.6.99.3

Names

Accepted name:
O-ureido-L-serine synthase
Other name:
dcsD (gene name)
Systematic name:
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase

Reaction

Comments:

The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y., Sugiyama, M.
    Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
    Antimicrob. Agents Chemother. 54: 1132-1139 (2010). [PMID: 20086163]
  2. Uda, N., Matoba, Y., Kumagai, T., Oda, K., Noda, M., Sugiyama, M.
    Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway.
    Antimicrob. Agents Chemother. 57: 2603-2612 (2013). [PMID: 23529730]

[EC 2.6.99.3 created 2013]