EC 2.4.1.301 - 2'-deamino-2'-hydroxyneamine 1-α-D-kanosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.301

Names

Accepted name:
2'-deamino-2'-hydroxyneamine 1-α-D-kanosaminyltransferase
Other names:
kanE (gene name)
kanM2 (gene name)
Systematic name:
UDP-α-D-kanosamine:2'-deamino-2'-hydroxyneamine 1-α-D-kanosaminyltransferase

Reactions

Comments:

Involved in the biosynthetic pathway of kanamycins. The enzyme characterized from the bacterium Streptomyces kanamyceticus can also accept UDP-α-D-glucose with lower efficiency [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kudo, F., Sucipto, H., Eguchi, T.
    Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster.
    J. Antibiot. 62: 707-710 (2009). [PMID: 19911031]
  2. Park, J. W., Park, S. R., Nepal, K. K., Han, A. R., Ban, Y. H., Yoo, Y. J., Kim, E. J., Kim, E. M., Kim, D., Sohng, J. K., Yoon, Y. J.
    Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
    Nat. Chem. Biol. 7: 843-852 (2011). [PMID: 21983602]

[EC 2.4.1.301 created 2013]