EC - Phenylpyruvate C3-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
phenylpyruvate C3-methyltransferase
Other names:
phenylpyruvate Cβ-methyltransferase
phenylpyruvate methyltransferase
mppJ (gene name)
Systematic name:
S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C3-methyltransferase



The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-β-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Huang, Y. T., Lyu, S. Y., Chuang, P. H., Hsu, N. S., Li, Y. S., Chan, H. C., Huang, C. J., Liu, Y. C., Wu, C. J., Yang, W. B., Li, T. L.
    In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin.
    Chembiochem 10: 2480-2487 (2009). [PMID: 19731276]

[EC created 2013]