EC 2.1.1.281 - Phenylpyruvate C3-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.281

Names

Accepted name:
phenylpyruvate C3-methyltransferase
Other names:
phenylpyruvate Cβ-methyltransferase
phenylpyruvate methyltransferase
mppJ (gene name)
Systematic name:
S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C3-methyltransferase

Reaction

Comments:

The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-β-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Huang, Y. T., Lyu, S. Y., Chuang, P. H., Hsu, N. S., Li, Y. S., Chan, H. C., Huang, C. J., Liu, Y. C., Wu, C. J., Yang, W. B., Li, T. L.
    In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin.
    Chembiochem 10: 2480-2487 (2009). [PMID: 19731276]

[EC 2.1.1.281 created 2013]