EC 1.1.1.360 - Glucose/galactose 1-dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.1.1.360

Names

Accepted name:
glucose/galactose 1-dehydrogenase
Other names:
GdhA
dual-specific glucose/galactose dehydrogenase
glucose (galactose) dehydrogenase
glucose/galactose dehydrogenase
Systematic name:
D-glucose/D-galactose 1-dehydrogenase (NADPH)

Reactions

Cofactor

Comments:

A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP+ compared to NAD+. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP+) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP+)).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Angelov, A., Futterer, O., Valerius, O., Braus, G. H., Liebl, W.
    Properties of the recombinant glucose/galactose dehydrogenase from the extreme thermoacidophile, Picrophilus torridus.
    FEBS J. 272: 1054-1062 (2005). [PMID: 15691337]
  2. Milburn, C. C., Lamble, H. J., Theodossis, A., Bull, S. D., Hough, D. W., Danson, M. J., Taylor, G. L.
    The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
    J. Biol. Chem. 281: 14796-14804 (2006). [PMID: 16556607]

[EC 1.2.1.88 created 2013]