EC 1.1.1.359 - Aldose 1-dehydrogenase [NAD(P)+]

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IntEnz Enzyme Nomenclature
EC 1.1.1.359

Names

Accepted name:
aldose 1-dehydrogenase [NAD(P)+]
Systematic name:
an aldopyranose:NAD(P)+ 1-oxidoreductase

Reactions

Comments:

The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Giardina, P., de Biasi, M. G., de Rosa, M., Gambacorta, A., Buonocore, V.
    Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus.
    Biochem. J. 239: 517-522 (1986). [PMID: 3827812]
  2. Smith, L. D., Budgen, N., Bungard, S. J., Danson, M. J., Hough, D. W.
    Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum.
    Biochem. J. 261: 973-977 (1989). [PMID: 2803257]
  3. Lamble, H. J., Heyer, N. I., Bull, S. D., Hough, D. W., Danson, M. J.
    Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.
    J. Biol. Chem. 278: 34066-34072 (2003). [PMID: 12824170]
  4. Theodossis, A., Milburn, C. C., Heyer, N. I., Lamble, H. J., Hough, D. W., Danson, M. J., Taylor, G. L.
    Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 112-115 (2005). [PMID: 16508107]
  5. Milburn, C. C., Lamble, H. J., Theodossis, A., Bull, S. D., Hough, D. W., Danson, M. J., Taylor, G. L.
    The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
    J. Biol. Chem. 281: 14796-14804 (2006). [PMID: 16556607]
  6. Haferkamp, P., Kutschki, S., Treichel, J., Hemeda, H., Sewczyk, K., Hoffmann, D., Zaparty, M., Siebers, B.
    An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation?
    Biochem. Soc. Trans. 39: 77-81 (2011). [PMID: 21265750]

[EC 1.2.1.87 created 2013]