EC 2.7.1.178 - 2-dehydro-3-deoxyglucono/galactono-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.178

Names

Accepted name:
2-dehydro-3-deoxyglucono/galactono-kinase
Other names:
KDG kinase [ambiguous]
KDGK [ambiguous]
2-keto-3-deoxy-D-gluconate kinase [ambiguous]
Systematic name:
ATP:2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase

Reactions

Comments:

The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC 2.7.1.45, 2-dehydro-3-deoxygluconokinase and EC 2.7.1.58, 2-dehydro-3-deoxygalactonokinase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lamble, H. J., Theodossis, A., Milburn, C. C., Taylor, G. L., Bull, S. D., Hough, D. W., Danson, M. J.
    Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
    FEBS Lett. 579: 6865-6869 (2005). [PMID: 16330030]
  2. Potter, J. A., Kerou, M., Lamble, H. J., Bull, S. D., Hough, D. W., Danson, M. J., Taylor, G. L.
    The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase.
    Acta Crystallogr. D Biol. Crystallogr. 64: 1283-1287 (2008). [PMID: 19018105]
  3. Kim, S., Lee, S. B.
    Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in the modified Entner-Doudoroff pathway.
    Biosci. Biotechnol. Biochem. 70: 1308-1316 (2006). [PMID: 16794308]

[EC 2.7.1.178 created 2013]