EC - Cyclo(L-leucyl-L-phenylalanyl) synthase

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IntEnz Enzyme Nomenclature


Accepted name:
cyclo(L-leucyl-L-phenylalanyl) synthase
Other names:
cFL synthase
Systematic name:
L-leucyl-tRNALeu:L-phenylalanyl-tRNAPhe leucyltransferase (cyclizing)



The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue [2]. The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Gondry, M., Sauguet, L., Belin, P., Thai, R., Amouroux, R., Tellier, C., Tuphile, K., Jacquet, M., Braud, S., Courcon, M., Masson, C., Dubois, S., Lautru, S., Lecoq, A., Hashimoto, S., Genet, R., Pernodet, J. L.
    Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
    Nat. Chem. Biol. 5 : 414-420 (2009). [PMID: 19430487]
  2. Sauguet, L., Moutiez, M., Li, Y., Belin, P., Seguin, J., Le Du, M. H., Thai, R., Masson, C., Fonvielle, M., Pernodet, J. L., Charbonnier, J. B., Gondry, M.
    Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis.
    Nucleic Acids Res. 39 : 4475-4489 (2011). [PMID: 21296757]

[EC created 2013]