EC 220.127.116.11 - Cyclo(L-leucyl-L-phenylalanyl) synthase
IntEnz Enzyme Nomenclature
- L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe = tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue . The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) .
Links to other databases
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.Nat. Chem. Biol. 5 : 414-420 (2009). [PMID: 19430487]
Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis.Nucleic Acids Res. 39 : 4475-4489 (2011). [PMID: 21296757]
[EC 18.104.22.168 created 2013]