EC - Cobalt-factor III methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
cobalt-factor III methyltransferase
Other name:
CbiH60 (gene name)
Systematic name:
S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting)



Isolated from Bacillus megaterium. The enzyme catalyses both methylation at C-17 and ring contraction. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Moore, S. J., Biedendieck, R., Lawrence, A. D., Deery, E., Howard, M. J., Rigby, S. E., Warren, M. J.
    Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway.
    J. Biol. Chem. 288: 297-305 (2013). [PMID: 23155054]

[EC created 2013]