EC - Cobalt-precorrin-4 methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
cobalt-precorrin-4 methyltransferase
Other name:
Systematic name:
S-adenosyl-L-methionine:cobalt-precorrin-4 11-methyltransferase



Part of the anaerobic route to adenosylcobalamin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Raux, E., Schubert, H. L., Woodcock, S. C., Wilson, K. S., Warren, M. J.
    Cobalamin (vitamin B12) biosynthesis--cloning, expression and crystallisation of the Bacillus megaterium S-adenosyl-L-methionine-dependent cobalt-precorrin-4 transmethylase CbiF.
    Eur. J. Biochem. 254: 341-346 (1998). [PMID: 9660189]
  2. Schubert, H. L., Wilson, K. S., Raux, E., Woodcock, S. C., Warren, M. J.
    The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase.
    Nat. Struct. Biol. 5: 585-592 (1998). [PMID: 9665173]
  3. Kajiwara, Y., Santander, P. J., Roessner, C. A., Perez, L. M., Scott, A. I.
    Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes.
    J. Am. Chem. Soc. 128: 9971-9978 (2006). [PMID: 16866557]

[EC created 2013]