EC 1.1.1.351 - Phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

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IntEnz Enzyme Nomenclature
EC 1.1.1.351

Names

Accepted name:
phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
Systematic name:
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase (decarboxylating)

Reactions

Comments:

The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Ben-Bassat, A., Goldberg, I.
    Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C.
    Biochim. Biophys. Acta 611: 1-10 (1980). [PMID: 7350909]
  2. Stournaras, C., Maurer, P., Kurz, G.
    6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and subunit structure.
    Eur. J. Biochem. 130: 391-396 (1983). [PMID: 6402366]
  3. Levy, H. R., Vought, V. E., Yin, X., Adams, M. J.
    Identification of an arginine residue in the dual coenzyme-specific glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides that plays a key role in binding NADP+ but not NAD+.
    Arch. Biochem. Biophys. 326: 145-151 (1996). [PMID: 8579362]

[EC 1.1.1.351 created 2013]