EC 2.1.1.n11 - Methylphosphotriester-DNA—[protein]-cysteine S-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.n11

This is a preliminary EC number. The content has not yet been validated and included in the official IUBMB Enzyme list.


Accepted name:
methylphosphotriester-DNA—[protein]-cysteine S-methyltransferase
Systematic name:
DNA (containing Sp-methylphosphotriester):[protein] L-cysteine methyltransferase




A Zn2+ protein. This protein is involved in the repair of Sp diastereomers of DNA methylphosphotriester lesions. This enzyme catalyses only one turnover and therefore is not strictly catalytic. The enzyme from the bacterium Escherichia coli also has the activity of EC, methylated-DNA—[protein]-cysteine S-methyltransferase, while the enzyme from Bacillus subtilis does not.

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Enzymes and pathways: ENZYME@ExPASy


  1. McCarthy, T. V., Lindahl, T.
    Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli.
    Nucleic Acids Res. 13: 2683-2698 (1985). [PMID: 2987862]
  2. Morohoshi, F., Munakata, N.
    Multiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agents.
    J. Bacteriol. 169: 587-592 (1987). [PMID: 3100503]
  3. Myers, L. C., Terranova, M. P., Ferentz, A. E., Wagner, G., Verdine, G. L.
    Repair of DNA methylphosphotriesters through a metalloactivated cysteine nucleophile.
    Science 261: 1164-1167 (1993). [PMID: 8395079]
  4. He, C., Hus, J. C., Sun, L. J., Zhou, P., Norman, D. P., Dotsch, V., Wei, H., Gross, J. D., Lane, W. S., Wagner, G., Verdine, G. L.
    A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.
    Mol. Cell 20: 117-129 (2005). [PMID: 16209950]

[EC 2.1.1.n11 created 2013]