EC 3.5.4.34 - TRNAAla(adenine37) deaminase

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IntEnz Enzyme Nomenclature
EC 3.5.4.34

Names

Accepted name:
tRNAAla(adenine37) deaminase
Other names:
ADAT1
Tad1p
Systematic name:
tRNAAla(adenine37) aminohydrolase

Reaction

Cofactor

Comments:

The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Maas, S., Gerber, A. P., Rich, A.
    Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes.
    Proc. Natl. Acad. Sci. U.S.A. 96: 8895-8900 (1999). [PMID: 10430867]
  2. Gerber, A., Grosjean, H., Melcher, T., Keller, W.
    Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2.
    EMBO J. 17: 4780-4789 (1998). [PMID: 9707437]
  3. Keegan, L. P., Gerber, A. P., Brindle, J., Leemans, R., Gallo, A., Keller, W., O'Connell, M. A.
    The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification.
    Mol. Cell. Biol. 20: 825-833 (2000). [PMID: 10629039]

[EC 3.5.4.34 created 2013]