EC 3.5.4.33 - TRNA(adenine34) deaminase

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IntEnz Enzyme Nomenclature
EC 3.5.4.33

Names

Accepted name:
tRNA(adenine34) deaminase
Other names:
tRNA:A34 deaminase
tadA protein
ADAT2-ADAT3 complex
TADA
tRNA adenosine deaminase arginine
AtTadA
tadA/ecADAT2
tRNA A:34 deaminase
Systematic name:
tRNA(adenine34) aminohydrolase

Reaction

Cofactor

Comments:

The enzyme is involved in editing of tRNA. The active site contains Zn2+ [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (35) [show] [UniProt]

References

  1. Spears, J. L., Rubio, M. A., Gaston, K. W., Wywial, E., Strikoudis, A., Bujnicki, J. M., Papavasiliou, F. N., Alfonzo, J. D.
    A single zinc ion is sufficient for an active Trypanosoma brucei tRNA editing deaminase.
    J. Biol. Chem. 286: 20366-20374 (2011). [PMID: 21507956]
  2. Delannoy, E., Le Ret, M., Faivre-Nitschke, E., Estavillo, G. M., Bergdoll, M., Taylor, N. L., Pogson, B. J., Small, I., Imbault, P., Gualberto, J. M.
    Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation.
    Plant Cell 21: 2058-2071 (2009). [PMID: 19602623]
  3. Kuratani, M., Ishii, R., Bessho, Y., Fukunaga, R., Sengoku, T., Shirouzu, M., Sekine, S., Yokoyama, S.
    Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus.
    J. Biol. Chem. 280: 16002-16008 (2005). [PMID: 15677468]
  4. Wolf, J., Gerber, A. P., Keller, W.
    tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli.
    EMBO J. 21: 3841-3851 (2002). [PMID: 12110595]
  5. Lee, W. H., Kim, Y. K., Nam, K. H., Priyadarshi, A., Lee, E. H., Kim, E. E., Jeon, Y. H., Cheong, C., Hwang, K. Y.
    Crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes.
    Proteins 68: 1016-1019 (2007). [PMID: 17554781]
  6. Ragone, F. L., Spears, J. L., Wohlgamuth-Benedum, J. M., Kreel, N., Papavasiliou, F. N., Alfonzo, J. D.
    The C-terminal end of the Trypanosoma brucei editing deaminase plays a critical role in tRNA binding.
    RNA 17: 1296-1306 (2011). [PMID: 21602302]

[EC 3.5.4.33 created 2013]