EC 4.2.1.136 - ADP-dependent NAD(P)H-hydrate dehydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.136

Names

Accepted name:
ADP-dependent NAD(P)H-hydrate dehydratase
Other names:
(6S)-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing)
(6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming)
Systematic name:
(6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming)

Reactions

Comments:

Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052855
UniProtKB/Swiss-Prot: (49) [show] [UniProt]

References

  1. Marbaix, A. Y., Noel, G., Detroux, A. M., Vertommen, D., Van Schaftingen, E., Linster, C. L.
    Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair.
    J. Biol. Chem. 286: 41246-41252 (2011). [PMID: 21994945]

[EC 4.2.1.136 created 2012]