EC 6.2.1.39 - [butirosin acyl-carrier protein]—L-glutamate ligase

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IntEnz Enzyme Nomenclature
EC 6.2.1.39

Names

Accepted name:
[butirosin acyl-carrier protein]—L-glutamate ligase
Other names:
[BtrI acyl-carrier protein]—L-glutamate ligase
BtrJ
Systematic name:
[BtrI acyl-carrier protein]:L-glutamate ligase (ADP-forming)

Reactions

Cofactor

Comments:

Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC 4.1.1.95, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second L-glutamate molecule. Requires Mg2+ or Mn2+, and activity is enhanced in the presence of Mn2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Li, Y., Llewellyn, N. M., Giri, R., Huang, F., Spencer, J. B.
    Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.
    Chem. Biol. 12: 665-675 (2005). [PMID: 15975512]

[EC 6.2.1.39 created 2012]