EC 1.2.1.84 - Alcohol-forming fatty acyl-CoA reductase

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IntEnz Enzyme Nomenclature
EC 1.2.1.84

Names

Accepted name:
alcohol-forming fatty acyl-CoA reductase
Other names:
FAR (gene name)
long-chain acyl-CoA:NADPH reductase
Systematic name:
NADPH:long-chain acyl-CoA reductase

Reactions

Comments:

The enzyme has been characterized from the plant Simmondsia chinensis (jojoba). The alcohol is formed by a four-electron reduction of fatty acyl-CoA. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. The recombinant enzyme was shown to accept saturated and mono-unsaturated fatty acyl-CoAs of 16 to 22 carbons.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102965
UniProtKB/Swiss-Prot: (21) [show] [UniProt]

References

  1. Metz, J. G., Pollard, M. R., Anderson, L., Hayes, T. R., Lassner, M. W.
    Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed.
    Plant Physiol. 122: 635-644 (2000). [PMID: 10712526]

[EC 1.2.1.84 created 2012]