EC 1.1.1.328 - Nicotine blue oxidoreductase

  IntEnz view ENZYME view

ENZYME: 1.1.1.328


ID   1.1.1.328
DE   Nicotine blue oxidoreductase.
CA   3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(P)(+) = (E)-
CA   2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione +
CA   NAD(P)H.
CC   -!- The enzyme, characterized from the nicotine degrading bacterium
CC       Arthrobacter nicotinovorans, catalyzes the reduction of 'nicotine
CC       blue' to its hydroquinone form (the opposite direction from that
CC       shown).
CC   -!- Nicotine blue is the name given to the compound formed by the
CC       autocatalytic condensation of two molecules of 2,3,6-
CC       trihydroxypyridine, an intermediate in the nicotine degradation
CC       pathway.
CC   -!- The main role of the enzyme may be to prevent the intracellular
CC       formation of nicotine blue semiquinone radicals, which by redox
CC       cycling would lead to the formation of toxic reactive oxygen species.
CC   -!- The enzyme possesses a slight preference for NADH over NADPH.
DR   Q93NF6    , NBOR_PAENI ;
//