EC 4.2.3.118 - 2-methylisoborneol synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.118

Names

Accepted name:
2-methylisoborneol synthase
Other names:
2-MIB cyclase
SCO7700 (gene name)
MIB synthase
MIBS
Systematic name:
(E)-2-methylgeranyl diphosphate lyase (cyclizing; 2-methylisoborneol-forming)

Reaction

Cofactor

Comments:

The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms. Formerly EC 4.2.3.n14.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Wang, C. M., Cane, D. E.
    Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
    J. Am. Chem. Soc. 130: 8908-8909 (2008). [PMID: 18563898]
  2. Komatsu, M., Tsuda, M., Omura, S., Oikawa, H., Ikeda, H.
    Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
    Proc. Natl. Acad. Sci. USA 105: 7422-7427 (2008). [PMID: 18492804]
  3. Giglio, S., Chou, W. K., Ikeda, H., Cane, D. E., Monis, P. T.
    Biosynthesis of 2-methylisoborneol in cyanobacteria.
    Environ. Sci. Technol. 45: 992-998 (2011). [PMID: 21174459]

[EC 4.2.3.118 created 2011]