EC 2.1.1.254 - Erythromycin 3''-O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.254

Names

Accepted name:
erythromycin 3''-O-methyltransferase
Other name:
EryG
Systematic name:
S-adenosyl-L-methionine:erythromycin C 3''-O-methyltransferase

Reactions

Comments:

The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102307 , GO:0102308
UniProtKB/Swiss-Prot:

References

  1. Paulus, T. J., Tuan, J. S., Luebke, V. E., Maine, G. T., DeWitt, J. P., Katz, L.
    Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.
    J. Bacteriol. 172: 2541-2546 (1990). [PMID: 2185226]
  2. Summers, R. G., Donadio, S., Staver, M. J., Wendt-Pienkowski, E., Hutchinson, C. R., Katz, L.
    Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
    Microbiology (Reading, Engl.) 143: 3251-3262 (1997). [PMID: 9353926]

[EC 2.1.1.254 created 2012]