EC - Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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IntEnz Enzyme Nomenclature


Accepted name:
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
Other name:
Systematic name:
L-erythro-7,8-dihydrobiopterin:NADP+ oxidoreductase



This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC, sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004757
CAS Registry Number: 9059-48-7


  1. Katoh, S.
    Sepiapterin reductase from horse liver: purification and properties of the enzyme.
    Arch. Biochem. Biophys. 146 : 202-214 (1971). [PMID: 4401291]
  2. Matsubara, M., Katoh, S., Akino, M. and Kaufman, S.
    Sepiapterin reductase.
    Biochim. Biophys. Acta 122 : 202-212 (1966). [PMID: 5969298]
  3. Werner, E.R., Schmid, M., Werner-Felmayer, G., Mayer, B. and Wachter, H.
    Synthesis and characterization of 3H-labelled tetrahydrobiopterin.
    Biochem. J. 304 : 189-193 (1994). [PMID: 7528005]
  4. Kim, Y.A., Chung, H.J., Kim, Y.J., Choi, Y.K., Hwang, Y.K., Lee, S.W. and Park, Y.S.
    Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli.
    Mol. Cells 10 : 405-410 (2000). [PMID: 10987137]

[EC created 1972, modified 2012]