EC 3.6.1.60 - Diadenosine hexaphosphate hydrolase (AMP-forming)

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IntEnz Enzyme Nomenclature
EC 3.6.1.60

Names

Accepted name:
diadenosine hexaphosphate hydrolase (AMP-forming)
Other names:
hAps1
NUDT11 (gene name)
hAps2
NUDT10 (gene name)
Systematic name:
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming)

Reactions

Comments:

A divalent cation is essential for activity. Mn2+ (2-6 mM) is most effective. The enzyme controls intracellular levels of P1,P5-bis(5'-adenosyl)pentaphosphate and P1,P6-bis(5'-adenosyl)hexaphosphate. Weak activity with P1,P4-bis(5'-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Leslie, N. R., McLennan, A. G., Safrany, S. T.
    Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.
    BMC Biochem. 3: 20 (2002). [PMID: 12121577]
  2. Safrany, S. T., Ingram, S. W., Cartwright, J. L., Falck, J. R., McLennan, A. G., Barnes, L. D., Shears, S. B.
    The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.
    J. Biol. Chem. 274: 21735-21740 (1999). [PMID: 10419486]

[EC 3.6.1.60 created 2012]