EC 1.16.1.9 - Ferric-chelate reductase (NADPH)

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ENZYME: 1.16.1.9


ID   1.16.1.9
DE   Ferric-chelate reductase (NADPH).
AN   Ferric chelate reductase.
AN   Iron chelate reductase.
AN   NADPH:Fe(3+)-EDTA reductase.
CA   2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH.
CF   FAD.
CC   -!- The enzyme, which is widespread among bacteria, catalyzes the
CC       reduction of ferric iron bound to a variety of iron chelators
CC       (siderophores), including ferric triscatecholates and ferric
CC       dicitrate, resulting in the release of ferrous iron.
CC   -!- The enzyme from the bacterium Escherichia coli has the highest
CC       efficiency with the hydrolyzed ferric enterobactin complex ferric
CC       N-(2,3-dihydroxybenzoyl)-L-serine.
CC   -!- Cf. EC 1.16.1.7 and EC 1.16.1.10.
DR   Q5A446    , FRE1_CANAL ;  P32791    , FRE1_YEAST ;  P36033    , FRE2_YEAST ;
DR   Q08905    , FRE3_YEAST ;  P53746    , FRE4_YEAST ;  Q08908    , FRE5_YEAST ;
DR   Q12473    , FRE6_YEAST ;  A6ZN61    , FRE7_YEAS7 ;  Q12333    , FRE7_YEAST ;
DR   Q04800    , FRP1_SCHPO ;  O94727    , FRP2_SCHPO ;  Q687X5-2  , STEA4-2_HUMAN;
DR   Q687X5    , STEA4_HUMAN;  Q923B6    , STEA4_MOUSE;  Q4V8K1    , STEA4_RAT  ;
DR   Q46871    , YQJH_ECOLI ;
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