EC - Ferric-chelate reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
ferric-chelate reductase (NADPH)
Other names:
ferric chelate reductase [ambiguous]
iron chelate reductase [ambiguous]
NADPH:Fe3+-EDTA reductase
NADPH-dependent ferric reductase
Fe(II):NADP+ oxidoreductase
Systematic name:
Fe(II)-siderophore:NADP+ oxidoreductase




Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [3]. cf. EC, ferric-chelate reductase (NADH) and EC, ferric-chelate reductase [NAD(P)H].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052851
UniProtKB/Swiss-Prot: (16) [show] [UniProt]


  1. Bamford, V. A., Armour, M., Mitchell, S. A., Cartron, M., Andrews, S. C., Watson, K. A.
    Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 : 792-796 (2008). [PMID: 18765906]
  2. Wang, S., Wu, Y., Outten, F. W.
    Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.
    J. Bacteriol. 193 : 563-574 (2011). [PMID: 21097627]
  3. Miethke, M., Hou, J., Marahiel, M. A.
    The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli.
    Biochemistry 50 : 10951-10964 (2011). [PMID: 22098718]

[EC created 1992 as EC, transferred 2002 to EC, transferred 2011 to EC, modified 2012, modified 2014]