EC 1.5.8.4 - Dimethylglycine dehydrogenase

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ENZYME: 1.5.8.4


ID   1.5.8.4
DE   Dimethylglycine dehydrogenase.
AN   Me2GlyDH.
CA   N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer
CA   flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced
CA   electron-transfer flavoprotein.
CF   FAD.
CC   -!- An imine intermediate is channeled from the FAD binding site to the
CC       5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel.
CC   -!- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms
CC       formaldehyde.
CC   -!- Formerly EC 1.5.99.2.
DR   Q9UI17-2  , M2GD-2_HUMAN;  Q9UI17    , M2GD_HUMAN ;  Q9DBT9    , M2GD_MOUSE ;
DR   Q63342    , M2GD_RAT   ;
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