EC 2.1.1.235 - DTDP-3-amino-3,6-dideoxy-α-D-glucopyranose N,N-dimethyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.235

Names

Accepted name:
dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose N,N-dimethyltransferase
Other name:
TylM1
Systematic name:
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose 3-N,N-dimethyltransferase

Reaction

Comments:

The enzyme is involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin, which is produced by the bacterium Streptomyces fradiae.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Chen, H., Yamase, H., Murakami, K., Chang, C. W., Zhao, L., Zhao, Z., Liu, H. W.
    Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
    Biochemistry 41: 9165-9183 (2002). [PMID: 12119032]
  2. Carney, A. E., Holden, H. M.
    Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose.
    Biochemistry 50: 780-787 (2011). [PMID: 21142177]

[EC 2.1.1.235 created 2011]