EC 2.1.1.234 - DTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose N,N-dimethyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.234

Names

Accepted name:
dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose N,N-dimethyltransferase
Other name:
DesVI
Systematic name:
S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose 3-N,N-dimethyltransferase

Reaction

Comments:

The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Chen, H., Yamase, H., Murakami, K., Chang, C. W., Zhao, L., Zhao, Z., Liu, H. W.
    Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
    Biochemistry 41: 9165-9183 (2002). [PMID: 12119032]
  2. Burgie, E. S., Holden, H. M.
    Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.
    Biochemistry 47: 3982-3988 (2008). [PMID: 18327916]

[EC 2.1.1.234 created 2011]