EC - Flavone 3'-O-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
flavone 3'-O-methyltransferase
Other names:
S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase
o-dihydric phenol meta-O-methyltransferase
o-dihydric phenol methyltransferase
o-diphenol m-O-methyltransferase
luteolin 3'-O-methyltransferase
luteolin methyltransferase
quercetin 3'-O-methyltransferase
Systematic name:
S-adenosyl-L-methionine:3'-hydroxyflavone 3'-O-methyltransferase



The enzyme prefers flavones with vicinal 3',4'-dihydroxyl groups.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030744 , GO:0102822
CAS Registry Number: 37205-55-3


  1. Ebel, J., Hahlbrock, K. and Grisebach, H.
    Purification and properties of an o-dihydricphenol meta-O-methyltransferase from cell suspension cultures of parsley and its relation to flavonoid biosynthesis.
    Biochim. Biophys. Acta 268 : 313-326 (1972). [PMID: 5026305]
  2. Muzac, I., Wang, J., Anzellotti, D., Zhang, H., Ibrahim, R. K.
    Functional expression of an Arabidopsis cDNA clone encoding a flavonol 3'-O-methyltransferase and characterization of the gene product.
    Arch. Biochem. Biophys. 375 : 385-388 (2000). [PMID: 10700397]
  3. Poulton, J. E., Hahlbrock, K., Grisebach, H.
    O-Methylation of flavonoid substrates by a partially purified enzyme from soybean cell suspension cultures.
    Arch. Biochem. Biophys. 180 : 543-549 (1977). [PMID: 18099]
  4. Kim, B. G., Lee, H. J., Park, Y., Lim, Y., Ahn, J. H.
    Characterization of an O-methyltransferase from soybean.
    Plant Physiol. Biochem. 44 : 236-241 (2006). [PMID: 16777424]
  5. Lee, Y. J., Kim, B. G., Chong, Y., Lim, Y., Ahn, J. H.
    Cation dependent O-methyltransferases from rice.
    Planta 227 : 641-647 (2008). [PMID: 17943312]

[EC created 1976, modified 2011]