EC 2.7.1.172 - Protein-ribulosamine 3-kinase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.7.1.172

Names

Accepted name:
protein-ribulosamine 3-kinase
Other names:
Fn3KRP
FN3K-related protein
FN3K-RP
ketosamine 3-kinase 2
fructosamine-3-kinase-related protein
ribulosamine/erythrulosamine 3-kinase
ribulosamine 3-kinase
Systematic name:
ATP:[protein]-N6-D-ribulosyl-L-lysine 3-phosphotransferase

Reactions

Comments:

This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines [1]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [2]. No activity with [protein]-N6-D-fructosyl-L-lysine [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102193
UniProtKB/Swiss-Prot:

References

  1. Collard, F., Delpierre, G., Stroobant, V., Matthijs, G., Van Schaftingen, E.
    A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines.
    Diabetes 52: 2888-2895 (2003). [PMID: 14633848]
  2. Fortpied, J., Gemayel, R., Stroobant, V., van Schaftingen, E.
    Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme.
    Biochem. J. 388: 795-802 (2005). [PMID: 15705060]
  3. Payne, L. S., Brown, P. M., Middleditch, M., Baker, E., Cooper, G. J., Loomes, K. M.
    Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine.
    Biochem. J. 416: 281-288 (2008). [PMID: 18637789]

[EC 2.7.1.172 created 2011]