EC 6.3.2.37 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase

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IntEnz Enzyme Nomenclature
EC 6.3.2.37

Names

Accepted name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
Other names:
UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase
D-lysine-adding enzyme
Systematic name:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate:D-lysine γ-ligase (ADP-forming)

Reaction

Comments:

Involved in the synthesis of cell-wall peptidoglycan. The D-lysine is attached to the peptide chain at the N6 position. The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102195
UniProtKB/Swiss-Prot:

References

  1. Boniface, A., Bouhss, A., Mengin-Lecreulx, D., Blanot, D.
    The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity.
    J. Biol. Chem. 281: 15680-15686 (2006). [PMID: 16595662]

[EC 6.3.2.37 created 2011, modified 2015]