EC 1.3.8.1 - Short-chain acyl-CoA dehydrogenase

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ENZYME: 1.3.8.1


ID   1.3.8.1
DE   Short-chain acyl-CoA dehydrogenase.
AN   Butanoyl-CoA dehydrogenase.
AN   Butyryl dehydrogenase.
AN   Short-chain acyl CoA dehydrogenase.
AN   Unsaturated acyl-CoA reductase.
CA   A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain
CA   trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
CF   FAD.
CC   -!- One of several enzymes that catalyze the first step in fatty acids
CC       beta-oxidation.
CC   -!- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA
CC       thioesters to give a trans 2,3-unsaturated product by removal of the
CC       two pro-R hydrogen atoms.
CC   -!- The enzyme from beef liver accepts substrates with acyl chain lengths
CC       of 3 to 8 carbon atoms.
CC   -!- The highest activity was reported with either butanoyl-CoA or
CC       pentanoyl-CoA.
CC   -!- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared
CC       to butanoyl-CoA) and no activity with octanoyl-CoA.
CC   -!- Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
CC   -!- Formerly EC 1.3.2.1 and EC 1.3.99.2.
PR   PROSITE; PDOC00070;
DR   Q3ZBF6    , ACADS_BOVIN;  P16219    , ACADS_HUMAN;  Q07417    , ACADS_MOUSE;
DR   P79273    , ACADS_PIG  ;  Q5RAS0    , ACADS_PONAB;  P15651    , ACADS_RAT  ;
DR   P52042    , ACDS_CLOAB ;  Q06319    , ACDS_MEGEL ;  Q0AVM4    , BCD1_SYNWW ;
DR   Q0AVA8    , BCD2_SYNWW ;  P26440-2  , IVD-2_HUMAN;  Q3SZI8    , IVD_BOVIN  ;
DR   P26440    , IVD_HUMAN  ;  Q9JHI5    , IVD_MOUSE  ;  Q5RBD5    , IVD_PONAB  ;
DR   P12007    , IVD_RAT    ;
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