EC 4.1.99.16 - Geosmin synthase

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IntEnz Enzyme Nomenclature
EC 4.1.99.16

Names

Accepted name:
geosmin synthase
Systematic name:
germacradienol geosmin-lyase (acetone forming)

Reactions

Cofactor

Comments:

Requires Mg2+. Geosmin is the cause of the characteristic smell of moist soil. It is a bifunctional enzyme. The N-terminal part of the enzyme is EC 4.2.3.22, germacradienol synthase, and forms germacradienol from FPP. The C-terminal part of the enzyme catalyses the conversion of germacradienol to geosmin via (1S,4aS,8aS)-8,10-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Jiang, J., He, X., Cane, D. E.
    Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.
    J. Am. Chem. Soc. 128: 8128-8129 (2006). [PMID: 16787064]
  2. Cane, D. E., He, X., Kobayashi, S., Omura, S., Ikeda, H.
    Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase.
    J. Antibiot. 59: 471-479 (2006). [PMID: 17080683]
  3. Jiang, J., He, X., Cane, D. E.
    Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme.
    Nat. Chem. Biol. 3: 711-715 (2007). [PMID: 17873868]

[EC 4.1.99.16 created 2011]