EC 4.1.99.16 - Geosmin synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.1.99.16
Names
Accepted name:
geosmin synthase
Systematic name:
germacradienol geosmin-lyase (acetone forming)
Reactions
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30371 [IUBMB](1E,4S,5E,7R)-germacra-1(10),5-dien-11-olName origin: UniProt - CHECKED (C)Formula: C15H26O
Charge: 0ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=(−)-geosminName origin: UniProt - CHECKED (C)Formula: C12H22O
Charge: 0ChEBI compound status: CHECKED (C) -
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-olName origin: UniProt - CHECKED (C)Formula: C15H26O
Charge: 0ChEBI compound status: CHECKED (C)=(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthaleneName origin: UniProt - CHECKED (C)Formula: C12H20
Charge: 0ChEBI compound status: CHECKED (C) -
(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthaleneName origin: UniProt - CHECKED (C)Formula: C12H20
Charge: 0ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=
Cofactor
Comments:
Requires Mg2+. Geosmin is the cause of the characteristic smell of moist soil. It is a bifunctional enzyme. The N-terminal part of the enzyme is EC 4.2.3.22, germacradienol synthase, and forms germacradienol from FPP. The C-terminal part of the enzyme catalyses the conversion of germacradienol to geosmin via (1S,4aS,8aS)-8,10-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene.
Links to other databases
UniProtKB/Swiss-Prot:
CYC2_STRCO
References
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Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.J. Am. Chem. Soc. 128 : 8128-8129 (2006). [PMID: 16787064]
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Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase.J. Antibiot. 59 : 471-479 (2006). [PMID: 17080683]
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Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme.Nat. Chem. Biol. 3 : 711-715 (2007). [PMID: 17873868]
[EC 4.1.99.16 created 2011]