EC 2.3.1.194 - Acetoacetyl-CoA synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.194

Names

Accepted name:
acetoacetyl-CoA synthase
Other name:
NphT7
Systematic name:
acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating)

Reaction

Comments:

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway. Unlike the homologous EC 2.3.1.180 (β-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Okamura, E., Tomita, T., Sawa, R., Nishiyama, M., Kuzuyama, T.
    Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
    Proc. Natl. Acad. Sci. USA 107: 11265-11270 (2010). [PMID: 20534558]

[EC 2.3.1.194 created 2011]