EC - Linoleate 11-lipoxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
linoleate 11-lipoxygenase
Other names:
linoleate dioxygenase
manganese lipoxygenase
Systematic name:
linoleate:oxygen 11S-oxidoreductase



The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13-hydroperoxyoctadeca-9,11-dienoate. The enzyme from the fungus Gaeumannomyces graminis requires Mn2+. It also acts on α-linolenate, whereas γ-linolenate is a poor substrate. Oleate and arachidonate are not substrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050584


  1. Hamberg, M., Su, C. and Oliw, E.H.
    Manganese lipoxygenase: Discovery of bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction.
    J. Biol. Chem. 273: 13080-13088 (1998). [PMID: 9582346]
  2. Oliw, E.H., Su, C., Skogstrom, T. and Benthin, G.
    Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn.
    Lipids 33: 843-852 (1998). [PMID: 9778131]
  3. Su, C. and Oliw, E.H.
    Manganese lipoxygenase: Purification and characterization.
    J. Biol. Chem. 273: 13072-13079 (1998). [PMID: 9582345]

[EC created 2000]